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KMID : 1231220230140010001
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Journal of the Korean Society for Research on Nicotine and Tobacco
2023 Volume.14 No. 1 p.1 ~ p.8
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Interaction between Smoking and Genetic Risk of FEV1/FVC Ratio in Chronic Lung Disease: A Cross-Sectional Study
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Lee Su-Hyun
Baek Ji-Woo
Jee Sun-Ha
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Abstract
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Background: Although lung function and smoking are risk factors for chronic lung disease (CLD), it is unclear whether the genetic risk score (GRS) for lung function is related to CLD prevalence and whether smoking has a synergistic effect. This study aimed to investigate whether the GRS for the forced expiratory volume in one second to the forced vital capacity (FEV1/FVC) ratio is associated with CLD, and if so, how smoking affects this association.
Methods: A genome-wide association study (GWAS) of the FEV1/FVC ratio was conducted, and the GRS for the FEV1/FVC ratio was generated. Multivariable regression was performed to estimate the odds ratio (OR) and 95% confidence intervals (CI) for the association between GRS for the FEV1/FVC ratio and smoking and CLD.
Results: A total of 8,166 participants (mean of age 52.18 years, 53.45% female) were included in this study. GRS, which contained 62 significant single-nucleotide polymorphisms identified in the GWAS for the FEV1/FVC ratio, had a strong association with CLD. The OR for CLD of those in the genetically low lung function and heavy smoking group was 3.01 times higher than that in the genetically high lung function and heavy smoking group (95% CI 1.07-10.7). Although no significant interaction was observed between GRS for CLD prevalence and smoking status (p for interaction=0.44), the OR of CLD for former smokers with genetically low lung function was 4.29 compared with non-smokers with genetically high lung function (95% CI 1.20-17.1).
Conclusion: GRS for the FEV1/FVC ratio was significantly associated with CLD. Participants with genetically low lung function were more likely to develop CLD when exposed to smoking.
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KEYWORD
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Chronic lung disease, Cross-sectional study, Smoking, Genetic risk score, Lung function, Interaction
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